Difference between Prokaryotic Cell and Eukaryotic Cell

A cell is the smallest structural unit of the body. Cells form entire tissue and organs and perform different functions of the body. Cells can be divided into two types based on the structure and functions; prokaryotic cell and eukaryotic cell. Both prokaryotic and eukaryotic cells have numerous differences.

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“Pro” means “old” and “karyon” means “nucleus”. In 1977, Carl Woese discovered prokaryotic cells (Archaea and Bacteria). A prokaryotic cell is the primitive kind of cell and has not some features as compared to the eukaryotic cell. History of the prokaryotic cells suggests that the evolution of the prokaryotic cell is at least 3.5 billion years old. But this kind of cell is still in use and has industrial importance. It is used in the fermentation process (Streptococcus, Lactobacillus) and for research work.

“Eu” means “new” and “kayron” means “nucleus”. Eukaryotic cell was discovered 2.7 billion years ago. Eukaryotic cells are the advanced kind of cells that are present in most plants and animals and fungi. These cells have a well-defined nucleus and possess different organelles for performing different complex functions.

Comparison Chart

Basis for ComparisonProkaryotic CellEukaryotic Cell
EtymologyPro means old and karyon means the nucleusEu means new and karyon means the nucleus
Size0.5-3 µm2-100 µm
Type of CellSingle-celledMulti celled
Cell WallPresent, composed of peptidoglycan or mucopeptideUsually absent, If present composed of cellulose
Shape of DNACircular, double-stranded DNALinear double-stranded DNA
NucleusNucleoid having DNAThe well-defined nucleus with a cell membrane
Mode of ReplicationAsexualSexual
Ribosomes70 S80 S
Golgi apparatusAbsentPresent
Endoplasmic ReticulumAbsentPresent
OrganellesOrganelles are usually absent if present not membrane-boundMostly present and always of membrane-bound, perform functions
Lysosomes and peroxisomesAbsentPresent
ChloroplastDispersed in cytoplasmPresent in plants and some algae
ReplicationSingle-origin of replicationMultiple origins of replications
Number of chromosomesOnly oneNumerous
Cell DivisionBinary fissionMitosis
Transcription and TranslationOccurs togetherTranscription occurs in the nucleus, translation occurs in the cytosol
ExampleArchaea, BacteriaPlants and animals
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What is Prokaryotic Cell?

Prokaryotic cell is the primitive cell and its generalized structure consists of the glycocalyx, nucleoid, pilus, mesosomes, flagellum, cell wall, fimbriae, granules, cell membrane and endospore.

Glycocalyx is a layer that functions as a receptor and also acts as a cell wall. Nucleoid is the condensed DNA packet material. Pilus is the hair-like hollow structure that is used to transfer DNA to other cells.

Flagellum is the structure which helps in movement. Extension of the cell membrane is called mesosome which helps in cellular respiration. The cell wall of the prokaryotic cell provides support and rigidity to the cell.

Fimbriae are other hair-like structures that help in attachment with other cells during mating. Some granules are also present in this type of cell which helps it to store carbohydrates, phosphate, glycogen, fats in the form of small particles for later use.

Ribosomes are tiny particles that help in protein synthesis. Cell membrane of prokaryotic cells is made up of proteins and lipids which surround the cytoplasm. Cell membrane helps the flow of material inside and outside the cell. Endospore helps the cell in surviving during harsh conditions.

Prokaryotic cells are classified into gram-positive and gram-negative bacteria on the basis of the presence of peptidoglycan. Gram-positive bacteria have a large amount of peptidoglycan in the cell wall whereas gram-negative bacteria have a thin layer of peptidoglycan.

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What is Eukaryotic Cell?

Eukaryotic cells have various structures such as the nucleus, cytoplasm, appendages, cell wall, cell membrane, ribosomes and cytoskeleton. Nucleus of eukaryotic cells is clearly defined with nuclear membrane. The genetic material of nucleus helps in the production of protein synthesis and ribosomes.

Cytoplasm contains organelles that perform metabolic activities of the cell. Mitochondria, chloroplast, Golgi apparatus and endoplasmic reticulum are different organelles present in cytoplasm.

Mitochondria make ATPs and are called powerhouses of the cell. Chloroplasts are present in certain algae and plant cells and involve in photosynthesis. Golgi apparatus are disc shaped sacs which are lied on each other. These sacs help in the packaging of cell material and secretion at the places where is required. Golgi apparatus form lysosomes and vacuoles which are involved in intracellular digestion with the help of enzymes. Vacuoles perform endocytosis for the cell.

Endoplasmic reticulum is of two types of smooth reticulum and rough reticulum and helps in the transportation of proteins, lipids and other material. Cilia and flagella are appendages that help in locomotion towards positive stimuli. Cilia are numerous and shorter than flagella. Glycocalyx of the eukaryotic cell is composed of polysaccharide, present on the outer surface of the cell. It aids in cell adherence, protection and sending signals to other cells.

Cell membrane or cytoplasmic membrane is a thin layer surrounding the cytoplasm. It provides protection to the entire cell and regulates the material movement inside and outside. It is composed of phospholipids embedded in proteins. It is the outermost layer in animal cells whereas in plants cell, it is surrounded by tough cell wall. Cell wall provides support, rigidity and shape to the cell.

Cellulose, chitin, pectin or peptidoglycan is its composting materials. Eukaryotic cells have 80S ribosomes which are tiny in nature and help in protein synthesis for the cell. Cytoskeleton is also the supporting framework of a eukaryotic cell. It is of two types; microtubules and microfilaments. Microtubules are made up of a protein called tubulin and have a diameter of about 24 nanometers. Microfilaments have a diameter of 6 nanometers and are composed of actin protein. These are the largest filaments while microtubules are the smallest units.

Key Differences between Prokaryotic Cell and Eukaryotic Cell

  1. Prokaryotic cells are the primitive type of cells whereas eukaryotic cells are the advanced cells,
  2. Prokaryotic cells have dense-packed DNA without cell wall whereas eukaryotic cells have a well-defined nucleus with boundary.
  3. Prokaryotic cell is actually a single-celled organism whereas eukaryotic cells are present in multi-celled organisms.
  4. Archeae and bacteria are examples of prokaryotic cells whereas plant cell and animal cells are examples of eukaryotic cells.


Both prokaryotic and eukaryotic cells are types of cells but have many differences from each other. A prokaryotic cell is the primitive type of cell whereas eukaryotic cell is the advanced cell. Scientists study cells for the sack of research work in a different field.

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